The best weight loss injection currently available is tirzepatide , sold under the brand name Mounjaro in the UK. Clinical trials show that Mounjaro supports an average weight loss of around 25% after one year, which is higher than other options
. Other notable weight loss injections include:
- Semaglutide (Wegovy) : Leads to about 15-17% average weight loss and is FDA-approved for chronic weight management
- Liraglutide (Saxenda) : Results in about 5-8% average weight loss, administered daily
- Zepbound (tirzepatide) : A newer FDA-approved injection showing around 21% weight loss at the highest dose
Mounjaro works by mimicking two hormones, GLP-1 and GIP, which help regulate blood sugar, reduce appetite, slow digestion, and control energy balance, making it highly effective for weight loss
. It is injected once weekly, with doses gradually increased to a maintenance dose. In summary, Mounjaro (tirzepatide) is currently considered the most effective weight loss injection based on clinical evidence, followed by Wegovy (semaglutide) and then Saxenda (liraglutide)
