The longest stage of Alzheimer's disease is generally the moderate stage, also known as the middle stage. This stage can last the longest compared to the early and late stages, often lasting several years (about 2 to 7 years depending on the source). During this stage, individuals experience disabling symptoms and require more care, with a progressive decline in memory, cognitive abilities, and physical functions. More specifically, the seven- stage model of Alzheimer's disease describes stages 4 to 6 as the moderate phase, with stage 5 lasting about 1.5 years and stage 6 extending around 2.5 years. These middle stages combined often constitute the longest period in the disease progression, with increasing support needed for daily activities and personal care.