"Up First" is a podcast produced by NPR that provides a 10-minute briefing on the three biggest news stories of the day, along with reporting and analysis from NPR News. It is available on weekdays by 6 a.m. ET and covers a wide range of topics, including politics, international affairs, and human interest stories. The podcast is hosted by a team of NPR journalists and is also available on Saturdays and Sundays with additional content. The podcast aims to provide listeners with a quick and comprehensive overview of the days most important news.