what kind of vaclozba disease

The term "vaclozba disease" appears to be a misspelling or misunderstanding. Based on related search results, it seems the intended disease is "VEXAS syndrome," which stands for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome. VEXAS syndrome is a newly described, rare autoimmune and autoinflammatory disease mostly affecting adult men, typically over 50 years old. It is caused by a somatic mutation in the UBA1 gene located on the X chromosome. This gene mutation leads to widespread inflammation, blood abnormalities, and systemic symptoms such as fever, fatigue, joint inflammation, skin problems (like neutrophilic dermatitis and vasculitis), cartilage inflammation, and lung and eye inflammation. It can be severe and sometimes fatal, with symptoms resistant to many treatments except corticosteroids. Blood and bone marrow dysfunctions, including anemia and myelodysplastic syndrome, are common in patients with VEXAS. Thus, VEXAS is a multisystem, autoinflammatory disease driven by a genetic mutation acquired during life rather than inherited.