AST (aspartate aminotransferase) is an enzyme found in various tissues throughout the body, with the highest concentrations in the liver and heart. Normal levels of AST in the blood are typically below 40 units per liter (U/L) for adults
. However, levels above this range may indicate liver damage or other health conditions
. In adults, an AST level above 1,000 U/L is considered very high and may be a sign of liver injury or hepatitis
. AST levels above 200 U/L are generally considered high and may indicate severe liver damage or disease
. Significantly elevated AST levels can be a cause for concern, and they can be a sign of various health issues, including liver disease, hepatitis, cirrhosis, and liver cancer
. If AST levels are high, it may also be a sign of:
- Chronic hepatitis
- Damage from alcohol
- Cholestasis, a decrease in bile flow
- Heart, kidney, bone, or muscle damage
- Liver cancers
- Liver scarring, known as liver cirrhosis
Doctors may recommend certain lifestyle changes to lower liver enzymes, such as limiting or avoiding alcohol, eating a balanced diet, exercising regularly, and quitting smoking if relevant
