Brenton Strange got hurt on Sunday, October 6, 2025, during the Jacksonville Jaguars' Week 5 NFL game against the Kansas City Chiefs. He suffered a hip injury in the second quarter, which forced him to leave the game early and he was ruled out for the remainder of that game. The injury caused him to miss the subsequent game against the Seattle Seahawks. Before leaving the field, Strange had one catch for 22 yards in that game.