The second season of "Doc" officially started on Sunday, September 14, 2025, with the premiere episode titled "Her Heart." However, the regular Tuesday night slot return for the show is scheduled for Tuesday, September 23, 2025, at 9/8c on Fox. The season opener features a storyline about a desperate father making a sacrifice to secure his daughter's heart transplant and involves lead character Dr. Amy Larsen facing memories from her past.
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