when does grey's anatomy return

Grey's Anatomy will return with its season 22 premiere on Thursday, October 9, 2025, at 10/9c on ABC. New episodes will air weekly in the same time slot, and episodes will be available for streaming on Hulu the day after airing. Season 21 had a break over winter but concluded in May 2025, and season 22 is set to continue the story with 18 episodes starting in October 2025.