"Grey's Anatomy" is set to return for its 21st season on March 6, 2025, after a lengthy winter break. Following that, the 22nd season will premiere on October 9, 2025, with new episodes airing at 10 p.m. on ABC. The show has been moved up by a week from an initially planned October 16 start date for season 22. Fans can also stream new episodes on Hulu the day after they air on ABC.