Grey's Anatomy Season 22 will return on Thursday, October 9, 2025, airing at 10:00 PM Eastern/Pacific on ABC. New episodes will be released weekly in that timeslot, and the episodes will be available for streaming the next day on Hulu and Hulu on Disney+.
For context, the previous season, Season 21, returned from its winter break on March 6, 2025 , and Season 22 follows this with its fall premiere.
Thus, fans can look forward to new Grey's Anatomy episodes starting in early October 2025.
