Jonathan Taylor is expected to be back and ready for the 2025 NFL season opener, with no current injury listed as of late August 2025. He returned to OTAs and training camp this year after recovering from his recent ankle injuries. The Colts are counting on him to carry a heavy workload in 2025 as their lead running back, and he is projected to start the season fully healthy. His first game of the 2025 season is scheduled for September 7, 2025, against the Miami Dolphins.