when will brandon aiyuk be back

Brandon Aiyuk is expected to return to play around Week 6 of the 2025 NFL season, which would be approximately mid-October. He suffered a torn ACL and MCL in Week 7 of the 2024 season and has been on the Physically Unable to Perform (PUP) list. The San Francisco 49ers have indicated a target return for Week 6, but this timeline remains flexible depending on his recovery progress. If he stays on the PUP list at season start, he must miss at least the first four games, making Week 6 the earliest realistic return date. This means Aiyuk would likely return for the game against the Tampa Bay Buccaneers on October 12, 2025, but there is still some uncertainty about the exact timing and his level of effectiveness upon return.