Joe Mixon, the Houston Texans running back, will be eligible to return from the reserve/non-football injury list as soon as Week 5 of the 2025 NFL season, when the Texans face the Baltimore Ravens. However, his actual return remains uncertain, as he has missed all offseason training and has not resumed practice yet. The Texans' management has not committed to a firm timeline for his comeback, with the general manager stating they will evaluate his progress after the first four games before making a decision. Given these factors, while the earliest possible return is Week 5, it is unclear if or when Mixon will actually return to play this season.