Fertilization in a human female typically occurs in the fallopian tubes, specifically at the ampullary-isthmic junction, which is the region where the wider part (ampulla) meets the narrower part (isthmus) of the fallopian tube. This is the site where the sperm meets and penetrates the egg (ovum) after ovulation. After fertilization, the fertilized egg (zygote) moves through the fallopian tube toward the uterus for implantation.