Manchester is a prominent city located in the northwest region of England, United Kingdom. It is part of the Greater Manchester metropolitan county and lies relatively close to the Pennines mountain range. Geographically, Manchester is approximately 160 miles (257 kilometers) northwest of London, situated at latitude 53.4808° N and longitude 2.2426° W. The city is a major cultural and industrial hub in the UK, historically known as the world's first industrialized city during the Industrial Revolution. It is situated on the east bank of the River Irwell, near its confluence with the Rivers Medlock and Irk, and is bordered by the Cheshire Plain to the south and the Pennines to the north and east.