For Week 6 fantasy football defense starts, the top recommended defenses to start are:
- Green Bay Packers vs. Bengals: The Bengals have struggled offensively and allowed many turnovers and sacks, making Packers a strong start.
- Pittsburgh Steelers vs. Browns: The Steelers are coming off a bye and face a rookie quarterback with an offense that has been low scoring and turnover-prone.
- Philadelphia Eagles vs. Giants (Thursday night game): Eagles defense is highly ranked for this week.
- Denver Broncos vs. Jets: Broncos have a solid defense and the Jets offense has been weak.
- Los Angeles Rams vs. Ravens: Rams defense is strong, especially if the Ravens' Lamar Jackson is out.
Other notable recommended defenses include the Patriots, Raiders, and Seahawks depending on matchup specifics. Defenses to avoid starting include the Lions against Chiefs, Cardinals against Colts, and 49ers against Buccaneers due to strong opposing offenses or low turnover potential. This conclusion is based on matchup quality, opponent offensive struggles, and recent defensive performance trends for fantasy purposes in Week 6 of the 2025 NFL season.
