Canelo Álvarez has officially lost three times in his professional boxing career. His losses are to the following opponents:
- Floyd Mayweather Jr. in 2013 by majority decision when Canelo was 23 years old.
- Dmitry Bivol in 2022 by unanimous decision at light heavyweight.
- Terence Crawford in 2025 by unanimous decision.
These defeats came against undefeated champions at the peak of their careers, and no rematches were held for these losses. Canelo has otherwise had a highly successful career with 63 wins and 2 draws out of 68 fights, making him one of the top pound-for-pound boxers in the world.