Gennady "GGG" Golovkin has lost primarily to Saúl "Canelo" Álvarez. Their notable fights include:
- Golovkin's first professional loss was to Canelo Álvarez in their second fight in 2018 by majority decision, which cost Golovkin his undefeated record and multiple middleweight titles
- Golovkin also lost to Canelo Álvarez in their third fight in 2022 by unanimous decision
Aside from Canelo, Golovkin has not lost many fights; he defeated Sergiy Derevyanchenko in 2019 to regain titles, and there is no record of other losses besides the ones to Canelo and a draw in their first fight
. In summary, the main boxer who defeated GGG is Canelo Álvarez.
