Grey's Anatomy has killed off several notable characters over its run, with some of the most memorable deaths including:
- Monica Beltran was killed off in Season 22 after being crushed by hospital machinery in an explosion, a difficult but narrative-driven decision by the showrunner.
- Denny Duquette died after a heart transplant in Season 2, which deeply impacted Izzie Stevens.
- George O'Malley died after getting hit by a bus in Season 6.
- Lexie Grey died in a traumatic plane crash in Season 8.
- Mark Sloan also died from injuries sustained in the same plane crash, passing away on life support in Season 9.
- Derek Shepherd died following a car accident in Season 11.
- Other characters who have died include Reed Adamson, Henry Burton, and Craig Thomas due to various storylines throughout the series.
The death of Monica Beltran in the latest season was part of a major hospital explosion storyline, chosen after careful consideration of the story impact and character arcs. These character deaths are known for their emotional impact on both the audience and the cast, shaping the ongoing drama of Grey's Anatomy.
If specific character deaths or seasons are of interest, more detailed information can be provided.