The Detroit Lions lost to the following teams in the 2025 NFL season so far:
- Cleveland Browns (10-13)
- Cincinnati Bengals (11-34)
- Tampa Bay Buccaneers (16-20)
- Washington Football Team (31-45)
- Philadelphia Eagles (35-38)
- Green Bay Packers (13-27)
These losses occurred in the games played through November 27, 2025. The Lions won other games against teams like the Chicago Bears, Kansas City Chiefs, Minnesota Vikings, New York Giants, Dallas Cowboys, and Los Angeles Rams.
