Several main characters have been killed off on Grey's Anatomy over the years. Recently, in the Season 22 premiere, Dr. Monica Beltran (played by Natalie Morales) was killed off. She died from injuries sustained in a hospital explosion when machinery collapsed on her while she was trying to help save a young patient. This was a significant and emotional death for the show, with the character dying in the line of duty as a pediatric surgeon. Meanwhile, another character, Dr. Atticus "Link" Lincoln, survived severe injuries from the same explosion.
Other notable characters who have been killed off in earlier seasons include:
- Denny Duquette, who died due to complications after a heart transplant in Season 2.
- Andrew DeLuca, stabbed and later died in Season 17.
- Lexie Grey and Mark Sloan, who died after a plane crash in Season 8.
- Derek Shepherd, who died after a car accident in Season 11.
The show has a history of dramatic character deaths that impact the storyline deeply.