The San Francisco 49ers won the game against the Los Angeles Rams with a final score of 26-23 in overtime on October 2, 2025. Despite being short-handed due to key injuries, the 49ers managed to hold off the Rams' late rally and secured the victory with a critical defensive stop on fourth down in overtime. Eddy Piñeiro kicked the winning 41-yard field goal in overtime, and the 49ers' defense prevented the Rams from converting on a pivotal fourth down with 3:36 left in the extra period. Mac Jones led the 49ers with 342 passing yards and two touchdowns, playing through a leg injury.
