People say "bless you" when someone sneezes mostly due to historical and superstitious reasons. One common origin traces back to the Middle Ages during the bubonic plague when sneezing was a symptom, and the phrase "God bless you" was a prayer to protect the person from death. Another belief is that a sneeze might expel the soul from the body, so saying "bless you" was meant to safeguard the soul from evil spirits or the devil. Today, it's mostly a polite social custom without serious superstition behind it. In some cultures, other expressions for health and well-being are used, such as "Gesundheit" in German, meaning "health".

