Sinensetin is an important polymethoxylated flavonoid found in plants like Orthosiphon aristatus (a medicinal plant) and citrus fruits. It is significant due to its strong anticancer activities and a wide range of other pharmacological benefits including anti-inflammatory, antioxidant, antimicrobial, anti-obesity, anti-dementia, and vasorelaxant effects. Studies have shown that sinensetin can act as a potential lead molecule for drug discovery with minimal toxicity. Its various mechanisms of actions in cancer and other diseases are being studied for better understanding, and it also shows promise as a chemosensitizing agent without inducing resistance mechanisms like P-gp activation. Furthermore, sinensetin exhibits antiangiogenesis effects, which contribute to its therapeutic potential in chronic inflammation and cancer treatment.
In summary, sinensetin is important due to its potent pharmacological activities with therapeutic potential in cancer, inflammation, and other disease conditions.
