Brock Purdy is not playing because he is dealing with a turf toe variant injury and a left shoulder issue that he sustained during the San Francisco 49ers' season opener. The toe injury, described as similar to turf toe but in an unusual location, is particularly concerning and is expected to sideline him for multiple weeks, with estimates ranging from 2 to 5 weeks. Due to these injuries, Purdy did not practice and was ruled out for Week 2 against the New Orleans Saints, with Mac Jones starting in his place. The 49ers are assessing his status on a week-to-week basis, and while there is a slight chance he could return as early as Week 3, the team is not optimistic about his immediate return yet. Purdy is considered "week to week" as he recovers, but the injury is limiting his playing ability, especially in pushing off his big toe for running and throwing.