In the event of an explosion on a large plant floor followed by billowing smoke, debris, and the fire alarm going off, the safest action is generally to evacuate the area rather than shelter in place. Explosions create immediate danger, with risks from fire, structural damage, and hazardous material release, so evacuating the premises quickly and safely is critical. Sheltering in place is usually recommended for chemical emergencies or short-term hazardous releases when officials instruct people to stay indoors and seal the environment to avoid exposure. However, in a scenario involving an explosion, smoke, and fire alarms going off, the priority is to raise the alarm, follow evacuation routes, and leave the area to avoid injury or exposure to hazards caused by the explosion and ensuing fire or debris. Evacuation plans should be followed according to the plant's emergency procedures.
Therefore, in this situation, do not shelter in place; instead, immediately evacuate the plant floor and move to a safe location as directed by emergency response protocols.