Without insurance, the cost of tirzepatide typically ranges from about $1,060 to $1,600 per month. This price applies to brand-name tirzepatide products like Mounjaro and Zepbound. The average retail list price is around $1,080 to $1,086 monthly without discounts or insurance coverage. Some discount programs or manufacturer self-pay programs may reduce costs somewhat, but out-of-pocket expenses for uninsured patients generally remain in the high hundreds to over a thousand dollars per month range.