Yes, creatine can be taken on an empty stomach and it is generally safe to do so. However, taking creatine without food may cause digestive discomfort in some people, such as bloating, nausea, gas, or stomach cramps. This is because creatine draws water into the intestines, which can create osmotic pressure and cause stomach upset especially if no food buffers the effect. Taking creatine on an empty stomach could lead to faster absorption since there is no food to slow its passage into the intestines and subsequently into the bloodstream. This might be beneficial for those who train in a fasted state or want quick uptake. However, creatine absorption may be enhanced when taken with carbohydrates, which stimulate insulin production that helps shuttle creatine into muscle cells. Thus, taking creatine with food or carbs may improve how much creatine your muscles can use. People sensitive to creatine or new to supplementation are more likely to experience stomach issues when taking it on an empty stomach. To minimize side effects, they could try taking creatine with a light meal or with sufficient water. Overall, taking creatine empty stomach or with food depends on personal preference, tolerance, and training goals, with consistent use being key for effectiveness.