It is generally safe to take ibuprofen together with methocarbamol. These two medications do not have known drug interactions and do not affect each other's behavior in the body. Methocarbamol is a muscle relaxant, while ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces pain and inflammation through different mechanisms, making their combined use common for muscle pain and spasms. However, both drugs can cause side effects such as drowsiness and dizziness, and taking them together may increase these risks. Additionally, people with liver or kidney problems, or those with certain pre-existing conditions like heart issues or stomach ulcers, should consult their healthcare provider before using these medications together. It is also recommended to avoid alcohol use while on these medications due to increased side effect risks. Overall, it is important to use this combination under medical guidance to ensure safety and appropriate dosing.