It is generally considered safe to drink alcohol in moderation while taking nitrofurantoin. There is no known direct interaction between nitrofurantoin and alcohol, so moderate drinking does not typically interfere with the medication's effectiveness. However, alcohol is a bladder irritant and may worsen urinary tract infection symptoms or side effects like nausea, dizziness, and drowsiness associated with nitrofurantoin. Therefore, it is advisable to either avoid or minimize alcohol consumption during treatment with nitrofurantoin to avoid exacerbating symptoms and side effects. Also, avoid excessive alcohol intake to allow the body to heal and to reduce the risk of adverse effects. After completing the medication course, alcohol can generally be consumed without restriction, but it may be wise to wait 48 hours to ensure full recovery.