It is generally safe for most people to drink a small amount of alcohol, such as one glass of wine, beer, or spirits, while taking ibuprofen 800 mg. However, drinking moderate to excessive amounts of alcohol while using ibuprofen can increase the risk of side effects like stomach irritation, digestive tract bleeding, ulcers, and kidney damage. Both alcohol and ibuprofen can irritate the stomach lining, so their combination raises risks more than either alone. People with underlying health conditions such as liver or kidney disease, high blood pressure, or heart failure are at higher risk from this combination. Experts advise taking ibuprofen with food to help protect the stomach. If alcohol is consumed with ibuprofen, it is best to limit the alcohol intake and avoid heavy drinking. Also, waiting several hours between drinking alcohol and taking ibuprofen is recommended to minimize risk. If symptoms like stomach pain, vomiting blood, black stools, dizziness, or swelling occur, medical attention should be sought immediately. In summary, occasional light drinking with ibuprofen 800 mg may be okay for healthy individuals, but combining them frequently or consuming larger amounts of alcohol can be dangerous and increase the risk of serious gastrointestinal and kidney problems.