It is generally not safe to drink alcohol while taking meloxicam. Combining meloxicam, a nonsteroidal anti-inflammatory drug (NSAID), with alcohol increases the risk of serious side effects including gastrointestinal (GI) bleeding, stomach ulcers, and liver damage. Both substances can irritate the stomach lining, reduce protective mucus, and increase the chance of stomach pain, ulcers, and bleeding. Additionally, alcohol and meloxicam together stress the liver, potentially causing liver inflammation or damage. While occasional light to moderate drinking may sometimes be tolerated by low- risk individuals, it is still recommended to avoid alcohol while on meloxicam, especially if there are underlying conditions such as liver disease, kidney problems, or a history of ulcers or bleeding. If alcohol is consumed, it is best to wait at least 12 to 24 hours after drinking before taking meloxicam and to do so only with a doctor's approval. Severe symptoms after drinking on meloxicam can include black or tarry stools, vomiting blood, jaundice, stomach pain, and nausea, which require immediate medical attention. In summary, alcohol use with meloxicam is best avoided due to increased risks of GI bleeding, ulcers, and liver damage. Consultation with a healthcare provider is essential for personalized advice on alcohol use during meloxicam treatment.