Yes, Prozac (fluoxetine) can make some people feel tired or fatigued, especially during the first few weeks of treatment. This tiredness is generally temporary and often improves within 4 to 6 weeks as the body adjusts to the medication. However, the effect of Prozac on energy levels varies from person to person; some may feel more energized or have trouble sleeping instead of feeling tired. Fatigue is a recognized side effect but is not experienced by everyone taking Prozac. If tiredness occurs, adjusting the timing of the dose or making lifestyle changes can help manage this effect, but it is important to discuss any concerns with a healthcare provider.