The search results provide information on herbal pathways, including positive and negative aspects, ingredients, and materials. Here are some key takeaways:
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Herbal medicines are in widespread use, and while many believe they are safe, they are often used in combination and are drawn from plant sources with their own variability in species, growing conditions, and biologically active constituents. Herbal extracts may be contaminated, adulterated, and may contain toxic compounds. The quality control of herbal medicines has a direct impact on their safety and efficacy.
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Preparation is an issue affecting herbal supplements. Herb preparation and the parts used significantly affect its efficacy and attributes. For example, Echinacea’s various effects depend on what part of the plant gets harvested, i.e., flowers, roots, or leaves. St. John’s Wort’s different benefits depending on the geographic location it was harvested from, its harvest time, whether fresh or dried plant material underwent processing, etc. .
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The Natural and Non-Prescription Health Products Directorate (NNHPD) requires information on the characterization of medicinal ingredients in herbal supplements. Additional guidance for medical and non-medicinal ingredients can be found in the Natural Health Products Ingredients Database (NHPID). The NHPID also contains descriptions and information regarding specific test methods that are acceptable for the criteria specified.
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The study of cannabis and cannabis-derived compounds in clinical trial settings is needed to assess the safety and effectiveness of these substances for the treatment of any disease or condition. The FDA has provided specific recommendations on submitting INDs for botanical drug products, such as those derived from cannabis, in support of future marketing applications for these products.
In summary, herbal pathways involve a complex set of factors that can affect their efficacy and safety. It is important to understand the quality control of herbal medicines, herb preparation, and the characterization of medicinal ingredients in herbal supplements. Additionally, clinical trials are needed to assess the safety and effectiveness of cannabis and cannabis-derived compounds.
