Wegovy works for weight loss by mimicking a natural hormone called glucagon- like peptide-1 (GLP-1) that regulates appetite in the brain. It activates GLP-1 receptors, which reduces hunger, helps people feel fuller longer by slowing stomach emptying, and leads to eating fewer calories. This sustained appetite reduction and increased satiety aid in significant and long-term weight loss when combined with diet and exercise.
Mechanism of Action
- Wegovy contains semaglutide, a GLP-1 receptor agonist that acts on the brain's appetite centers.
- It slows down gastric emptying, prolonging fullness after meals.
- Semaglutide also influences insulin production and glucose regulation, contributing to metabolic benefits.
Effects on Weight Loss
- Users typically eat less because of suppressed appetite and enhanced fullness.
- Clinical studies show average weight loss of about 15% of body weight over two years, significantly more than placebo.
- Weight loss maintenance is supported over long periods with ongoing treatment.
In summary, Wegovy's efficacy for weight loss stems from its ability to reduce appetite and increase satiety by mimicking GLP-1 hormone activity, combined with lifestyle changes.
