Mucinex, which contains the active ingredient guaifenesin, generally begins to work within about 45 minutes after taking the medication. It helps by thinning and loosening mucus in the airways, making coughs more productive and clearing chest congestion more effectively. This timing is related to the peak plasma concentrations of guaifenesin for immediate-release formulations. For extended-release forms, symptom relief can last up to 12 hours. It's also advised to drink plenty of fluids with Mucinex to help loosen mucus further. If symptoms persist or worsen beyond 5 to 7 days, consulting a doctor is recommended.
