Prilosec (omeprazole) usually starts to work within 1 to 4 days, with some people experiencing complete relief of symptoms within 24 hours. However, it may take up to 4 weeks to feel the full effect of the medication, especially for conditions like acid reflux or GERD. It is important to take it as directed, typically once a day before eating, and not to expect immediate relief since it works by reducing stomach acid production over time rather than neutralizing acid immediately.
