Seroquel (quetiapine) typically starts working for some symptoms within 1 to 3 weeks, but it usually takes about 2 to 3 months to experience its full therapeutic effects. The sedative effects can be noticed within hours, but mood stabilization and symptom improvement such as reduced hallucinations, delusions, or mood episodes develop gradually over weeks to months. For conditions like schizophrenia and bipolar disorder, early improvements may be seen around 2 to 3 weeks, with full benefits often requiring up to 2 or 3 months of consistent use. Taking Seroquel at bedtime is common to reduce daytime drowsiness. The exact timeframe can vary based on individual factors, dosage, and the specific condition being treated.