Sertraline usually starts to have some effect within 1 to 2 weeks, especially improvements in sleep, energy, or appetite. However, it generally takes about 4 to 6 weeks to feel the full therapeutic benefits for mood, anxiety, or depression symptoms. In some cases, it may take longer, and initial worsening of symptoms can occur before improvement is noticed. It is important to continue taking the medication as prescribed and to consult a healthcare provider if no benefits are felt after around 6 weeks.
