A slice of pepperoni pizza typically contains between 165 and 450 calories, depending on the size, crust type, and brand. For example:
- Hungry Howie's reports about 165 calories per slice of pepperoni pizza
- Papa John's 14" pepperoni pizza slice has around 338 calories
- Pizza Hut pepperoni pizza slices are about 220 calories each, with two slices totaling around 400-410 calories
- Larger or thicker crust pizzas, or those with more cheese and toppings, can have up to 450 calories per slice according to the National Heart, Lung, and Blood Institute
- A large pepperoni pizza slice from Pizza Pizza has about 230 calories
In summary, a typical slice ranges roughly from 165 to 350 calories, but can be higher depending on the pizza's size and preparation
