Mounjaro (tirzepatide) is generally considered safe when prescribed and used correctly under medical supervision, especially for managing type 2 diabetes and weight loss. Common side effects mainly affect the gastrointestinal system and include nausea, vomiting, diarrhea, decreased appetite, constipation, and abdominal pain. These side effects are usually mild to moderate and tend to improve over time as the body adjusts to the medication. Serious but less common side effects include pancreatitis (inflammation of the pancreas), severe digestive problems, hypoglycemia (low blood sugar), gallbladder disease, and possible severe allergic reactions. Mounjaro carries an FDA boxed warning about a possible risk of thyroid cancer, based on findings from animal studies, though human risk remains unclear. Patients with a personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 should not use Mounjaro. It is important to take Mounjaro strictly as prescribed, with doctors monitoring for any adverse effects, especially with regard to kidney health and hydration since vomiting or diarrhea can worsen kidney function. It is not safe during pregnancy or for those planning to become pregnant. Overall, the safety profile is well documented in clinical trials involving thousands of patients, and the medication is approved by regulatory agencies such as the FDA and MHRA for long-term use in appropriate candidates. Patients should report any side effects to their healthcare provider promptly and avoid unsupervised use of the drug.