Here are the details about Minocycline hyperpigmentation, positive and negative effects, and ingredients or materials:
- Minocycline is a semisynthetic derivative of tetracycline, used as an antibiotic to treat various bacterial infections.
- Minocycline-induced hyperpigmentation is a well-documented side effect of long-term treatment with minocycline. The risk of hyperpigmentation has been estimated at 2.4% to 14.8% .
- Three patterns of minocycline hyperpigmentation have been described: Type I hyperpigmentation is characterized by a blue-black color that occurs in sites of previous inflammation or scarring, typically within facial acne scars. Biopsy shows iron deposition in the dermis. Hyperpigmentation is most often noted to occur in the skin and gingival margin, but it may also involve sclera, teeth, and nails. Biopsy is the best way to confirm diagnosis, but this is often not necessary to establish the diagnosis. The condition usually resolves spontaneously within months to years after discontinuing the minocycline.
- Positive effects of minocycline include its effectiveness against most strains of gram-positive and gram-negative bacteria.
- Negative effects of minocycline include hyperpigmentation, autoimmune hepatitis, and hypersensitivity reactions.
- Inactive ingredients in minocycline hydrochloride tablets for oral administration include Microcrystalline Cellulose NF, Lactose Anhydrous NF, Povidone USP, Colloidal Silicon Dioxide NF, Magnesium Stearate NF, and Sodium Starch Glycolate NF. The 50 mg, 75 mg and 100 mg tablets also contain Opadry White which contains: Titanium Dioxide USP, Hypromellose Type 2910 USP, Polyethylene Glycol 400 NF, and Polysorbate 80 NF. The capsule shells of Minocin contain FD&C Blue #1, Gelatin, Titanium Dioxide and FD&C Yellow #10.
