Onychomycosis is a fungal infection of the nail unit. There are several products available for the treatment of onychomycosis, including topical and oral antifungal medications. Here are some details about onychomycosis products based on the search results:
Topical Antifungal Medications
- Ciclopirox 8% solution is the only topical prescription medication available in the United States for the treatment of onychomycosis. It is a synthetic hydroxypyridine antifungal formulated as a nail lacquer.
- Amorolfine (Loceryl/C210) is a nail lacquer that is specifically indicated for nail infection. It is recommended with a strength of recommendation B and quality of evidence II-ii.
- Tioconazole (Trosyl/C210) is a nail solution that is specifically indicated for nail infection. It is recommended with a strength of recommendation C and quality of evidence II-iii.
- Salicylic acid (Phytex/C210) is a paint that is used for the treatment of onychomycosis. It is recommended with a strength of recommendation E and quality of evidence IV.
- Undecenoates (Monphytol/C210) is a paint that is used for the treatment of onychomycosis. It is recommended with a strength of recommendation E and quality of evidence IV.
Oral Antifungal Medications
- Terbinafine (Lamisil) and itraconazole (Sporanox) are the most widely used oral antifungal medications for the treatment of onychomycosis. Fluconazole (Diflucan) is also gaining acceptance. These medications offer shorter treatment courses, higher cure rates, and fewer relapses.
- Mycological cure rates (negative KOH and culture) were significantly higher with efinaconazole compared to placebo.
It is important to note that accurate diagnosis is crucial for successful treatment and requires identification of physical changes and positive laboratory analysis. Treatment outcomes in patients with onychomycosis have improved substantially in recent years, primarily because of the introduction of more effective oral antifungal medications. Combination therapy with topical agents, periodic debridement, or chemical nail avulsion may produce better results than systemic medication alone.
