Taking Tylenol (acetaminophen) during pregnancy is generally considered safe when used as needed and in moderation. Medical experts and leading organizations like the American College of Obstetricians and Gynecologists (ACOG) endorse acetaminophen as the preferred over-the-counter medication for pain and fever relief during pregnancy. Over-the-counter alternatives like ibuprofen and naproxen are typically avoided, especially after 20 weeks, due to potential harm to the fetus. Recent extensive research, including a 2024 study, found no causal link between acetaminophen use during pregnancy and increased risks of autism or ADHD in children. While some studies have suggested a possible association, these findings have limitations and no conclusive evidence confirms that acetaminophen causes neurodevelopmental disorders. The FDA has initiated label changes to notify physicians about potential risks based on associations found in observational studies. Despite this, the benefits of treating pain and fever with acetaminophen during pregnancy, which can be harmful if untreated, generally outweigh the potential risks. Pregnant women are advised to take acetaminophen only when necessary, at the lowest effective dose, and after consulting with their healthcare provider. In summary, Tylenol can be taken during pregnancy safely when used appropriately under medical guidance, particularly for managing pain or fever when necessary to protect both mother and fetus.