systematic review

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Nature

A systematic review is a rigorous type of literature review that collects and critically analyzes multiple research studies or papers on a clearly defined topic using explicit, reproducible methods to minimize bias. It involves a structured process of defining a research question, setting criteria for study inclusion, systematically searching for relevant research, assessing study quality, and synthesizing findings, often quantitatively through meta- analysis. Systematic reviews aim to provide comprehensive, reliable, and evidence-based conclusions to inform research, policy, and practice.

Key Characteristics

  • Uses a clear, explicit research question and protocol often registered or published before review.
  • Follows a comprehensive, replicable search strategy for identifying relevant studies.
  • Includes critical appraisal of study quality and risk of bias.
  • Synthesizes data from multiple studies to draw well-founded conclusions.
  • Often involves more than one reviewer to enhance objectivity.

Process Stages

  • Defining a precise question (e.g., using PICO framework: Population, Intervention, Comparison, Outcome).
  • Developing inclusion and exclusion criteria for studies.
  • Systematic search across databases and other sources.
  • Screening and selecting studies based on eligibility.
  • Data extraction and quality assessment.
  • Data synthesis and, where applicable, meta-analysis.
  • Interpretation and reporting of results with transparency.

Systematic reviews are distinguished from traditional narrative reviews by their methodological rigor intended to minimize bias and provide more reliable evidence summaries.