The cast of the 2012 film "This Is 40" includes:
- Paul Rudd as Pete, Debbie's husband and a record label owner
- Leslie Mann as Debbie, Pete's wife and a shop owner
- Maude Apatow as Sadie, their 13-year-old daughter
- Iris Apatow as Charlotte, their 8-year-old daughter
- Jason Segel as Jason, Debbie's trainer
- Charlyne Yi as Jodi, one of Debbie's employees
- Tim Bagley as Dr. Pellegrino, Debbie's gynecologist
- John Lithgow as Oliver, Debbie's father
- Albert Brooks as Larry, Pete's father
- Megan Fox as Desi, one of Debbie's employees
- Chris O'Dowd as Ronnie, one of Pete's employees
- Melissa McCarthy as Catherine
- Ryan Lee as Joseph
- Lena Dunham as Cat, one of Pete's employees
- Robert Smigel as Barry, Pete's friend
- Annie Mumolo as Barb, Debbie's friend
- Ava Sambora as Wendy, Sadie's best friend
- Michael Ian Black as Bank Consultant
- Bill Hader as Desi's hook-up customer (uncredited)
- Billie Joe Armstrong, Graham Parker, Ryan Adams, Tom Freund, Bob Andrews, Brinsley Schwarz, Martin Belmont, Andrew Bodnar, and Steve Goulding as themselves
There are also cameos by Scott Hartnell, Ian Laperrière, James van Riemsdyk, Matt Carle, and Wyatt Russell.
