Trulicity is a medication used to control blood sugar and reduce cardiovascular risk in people with type 2 diabetes. It is not indicated for weight loss. However, people taking Trulicity may lose weight because of how it works in the body. Trulicity is a glucagon-like peptide-1 (GLP-1) medicine that slows down the stomach from emptying, which helps you feel full after eating. It also slows down the rate at which sugar is absorbed into the bloodstream, which helps keep blood sugar levels under control. In a clinical study, people who took Trulicity for 26 weeks lost 3 to 5 pounds. If you take Trulicity with other diabetes drugs, the amount of weight you lose may vary depending on the specific drugs you’re taking.
Here are some additional details about Trulicity:
Positive:
- Trulicity helps to lower the risk of certain cardiovascular problems in people with diabetes.
Negative:
- Trulicity is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with multiple endocrine neoplasia syndrome type 2 (MEN 2) .
- Trulicity may increase the risk of hypoglycemia, including severe hypoglycemia, in patients receiving it in combination with an insulin secretagogue (e.g., sulfonylurea) or insulin.
- Use of Trulicity may be associated with gastrointestinal adverse reactions, sometimes severe.
- Trulicity has not been studied in patients with severe gastrointestinal disease, including severe gastroparesis, and is therefore not recommended in these patients.
- Diabetic retinopathy complications have been reported in a cardiovascular outcomes trial, so patients with a history of diabetic retinopathy should be monitored.
- Limited data with Trulicity in pregnant women are not sufficient to determine a drug-associated risk for major birth defects and miscarriage.
Ingredients or materials:
- The active ingredient in Trulicity is dulaglutide, which is a synthetic peptide that acts like a naturally occurring hormone in the body called GLP-1.
- Other ingredients in Trulicity include citric acid anhydrous, mannitol, polysorbate 80, and trisodium citrate dihydrate in water for injection.
