what organ does ibuprofen affect

Ibuprofen affects the kidneys and rarely affects the liver. Ibuprofen and other non-steroidal anti-inflammatory drugs (NSAIDs) block a process in the body called the cyclooxygenase (COX) pathway, which is involved in creating pain and swelling. But it’s also involved in helping blood to flow to the kidneys. Blocking the COX pathway can narrow blood vessels leading to the kidneys, which can cause acute (sudden) kidney injury. Liver problems from using ibuprofen may develop in people at high risk of liver damage, such as those with cirrhosis or hepatitis C. Additionally, the risk is increased if ibuprofen is combined with medicines that are hard on the liver. Ibuprofen can affect liver function tests when taken in high doses, so people with liver problems or those taking medications that can harm the liver should consult their doctor to determine whether ibuprofen is harmful to their liver and to prescribe the right medication.