which part of the enzyme binds with the substrate?

The part of the enzyme that binds with the substrate is called the "active site." This site is a specific region on the enzyme composed of a unique combination of amino acid residues with different properties. The active site fits the substrate like a key in a lock, forming an enzyme-substrate complex. It includes a binding site that holds the substrate in the correct orientation and a catalytic site that facilitates the chemical reaction. The binding between the enzyme's active site and the substrate typically involves non- covalent interactions such as hydrogen bonds, van der Waals forces, hydrophobic interactions, and electrostatic interactions. This binding site is essential for the enzyme's specificity and catalytic activity.