The Arizona Cardinals will start Emari Demercado at running back for their game on Sunday, October 6, 2025, against the Tennessee Titans. This change comes after rookie Trey Benson was placed on injured reserve due to a knee injury, and lead back James Conner is already out for the season with a foot injury. Demercado is expected to handle more inside carries, while Michael Carter will share the workload, especially in passing situations. Bam Knight will also be part of the running back rotation but is currently the No. 3 option behind Demercado and Carter.